The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this practical episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—moves from theory to action. After exploring how glycation and advanced glycation end products (AGEs) drive aging and chronic disease, Dr. Reynolds now answers the critical question: What can we actually do about it? This episode dives into the science-backed tools that help slow glycation, reduce AGE accumulation, and calm RAGE-driven inflammation in the body. Drawing from peer-reviewed studies and clinical evidence, Dr. Reynolds breaks down the most promising supplements, dietary strategies, and metabolic interventions that target glycation at multiple levels—from carbonyl scavenging to antioxidant restoration and glucose control. You’ll learn how compounds like L-carnosine, pyridoxamine, GlyNAC, beta-hydroxybutyrate (BHB), and polyphenols from yerba mate may help intercept the glycation cascade before irreversible damage occurs. The episode also explores the emerging role of allulose as a low-glycation sugar substitute and explains why metabolic health strategies such as ketosis, improved insulin sensitivity, and blood-glucose control are central to slowing AGE formation. Most importantly, this lecture turns complex biochemical research into clear, actionable strategies for protecting long-term metabolic and cellular health. Topics Covered: -What glycation is and why AGEs accumulate in the body -The major drivers of glycation: glucose, fructose, and reactive carbonyl species -L-carnosine as a powerful carbonyl scavenger and anti-glycation compound -Pyridoxamine (vitamin B6) and B-vitamins as AGE inhibitors -GlyNAC (glycine + NAC) and restoring glutathione defenses -Beta-hydroxybutyrate (ketones) as a metabolic and anti-glycation signal -Yerba mate polyphenols and their AGE-blocking effects -Allulose as a low-glycation sugar alternative -Practical strategies to reduce AGE accumulation and improve metabolic health Timestamps 00:00 Introduction – Fighting Glycation: Practical Strategies 00:39 Quick Glycation Refresher (AGEs & RAGE Explained) 01:17 The Chemistry of Glycation (Maillard Reaction in the Body) 01:57 How AGEs Trigger Inflammation and Disease 02:39 The 3 Major Drivers of Glycation 04:04 Supplement #1: L-Carnosine 06:48 Supplement #2: Pyridoxamine (Vitamin B6 Form) 09:02 Supplement #3: NAC + Glycine (GlyNAC & Glutathione) 11:19 Supplement #4: Beta-Hydroxybutyrate (Ketones) 14:15 Supplement #5: Yerba Mate Polyphenols 16:22 Methylene Blue – Current Evidence 17:40 Allulose: A Low-Glycation Sugar Alternative 19:39 Electrolytes, Insulin Sensitivity & Glycation 20:20 Building an Anti-Glycation Protocol 22:25 Final Thoughts – Glycation and Aging 23:03 Closing Whether you're navigating diabetes, cardiovascular disease, neurodegeneration, or simply seeking to slow the biochemical drivers of aging, this episode provides practical, evidence-based tools to help you take action. About Dr. Paul Reynolds Dr. Reynolds is a dynamic educator and biomedical scientist at Brigham Young University, known for making complex metabolic pathways both understandable and engaging. His College of Glycation series empowers individuals to confront the silent molecular processes that drive aging and chronic disease. #supplements #antiglycation #yerbemate #exogenousketones #allulose #electrolytes #reduceglycation #reduceinflammation #insulinresistance #Glycation #AGEs #inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #Ketodiet #LowCarb #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #KetoDiet #LowCarb #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth #Keto #KetoCommunity #HealthEducation Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)