The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this essential episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—uncovers the hidden role of glycation in fertility and reproductive health. Building on prior explorations of glycation’s systemic effects, Dr. Reynolds now reveals how sugar-driven molecular damage disrupts both male and female reproduction—impacting conception, pregnancy, and the next generation. Glycation, through its toxic byproducts known as AGEs (advanced glycation end products), quietly interferes with sperm DNA, egg quality, endometrial receptivity, and placental function. These molecular disruptions connect directly to rising infertility, pregnancy complications, and conditions such as PCOS, endometriosis, male infertility, and gestational diabetes. With clarity and evidence, Dr. Reynolds explains why glycation is not just a metabolic nuisance but a root cause of reproductive decline. This lecture traces the science from pioneering studies to cutting-edge fertility research. Most importantly, it empowers viewers with strategies to reduce AGE burden—through diet, lifestyle, and emerging therapeutics—helping to restore fertility and protect reproductive health. Topics Covered: -What glycation is and how AGEs form -How AGEs damage sperm and impair DNA integrity -The link between glycation, PCOS, and poor egg quality -Glycation’s role in endometriosis and endometrial receptivity -Placental dysfunction, gestational diabetes, and pregnancy risks -Evidence-based strategies to reduce AGEs and improve fertility outcomes Timestamps: 00:00 – Introduction to Glycation & Fertility 00:38 – What is Glycation? (AGES explained) 01:20 – How Glycation Disrupts Reproductive Health 02:00 – Global Infertility Statistics & Causes 02:42 – PCOS and Its Connection to Glycation 03:23 – Endometriosis, Ovarian Reserve & Male Infertility 04:05 – Male Fertility and Glycation (Research Findings) 04:45 – AGEs in Sperm Cells & DNA Damage 05:23 – Studies Linking Glycation to Poor Sperm Quality 06:07 – Animal Studies Blocking AGEs (New Therapies) 06:52 – Glycation as a Driver of Male Infertility 07:35 – Female Fertility: PCOS & Insulin Resistance 08:17 – AGEs Impairing Egg Development & Ovulation 09:03 – IVF Studies: Glycation Reduces Fertility Outcomes 09:49 – Glycation Effects on Endometrium & Implantation 10:30 – Pregnancy Complications & Gestational Diabetes 11:14 – Lifestyle Solutions: Reducing Glycation 11:57 – Diet, Cooking Methods & Exercise Interventions 12:42 – Herbal & Therapeutic Advances in Fertility Care 13:25 – Rethinking Fertility: A Metabolic Perspective 14:04 – Closing Thoughts & Takeaway 14:44 – Final Thanks & Call to Action Whether you’re navigating infertility, pregnancy complications, or simply seeking to understand reproductive health at a deeper level, this episode offers the tools and science to take action. About Dr. Paul Reynolds Dr. Reynolds is a biomedical scientist and professor at Brigham Young University, known for making complex metabolic pathways engaging and practical. His College of Glycation series empowers individuals to understand and address the silent biochemical processes that drive aging, infertility, and chronic disease. #reproduction #reproductivehealth #fertility #pcos #endometriosis #infertility #placenta #gestationaldiabetes #Glycation #AGEs #inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #KetoDiet #LowCarb #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)