The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this foundational lecture for the College of Glycation, Dr. Paul Reynolds explains the process of glycation—how sugars spontaneously bond to proteins, fats, and DNA to form Advanced Glycation End-products (AGEs). These reactions contribute significantly to aging, chronic inflammation, and the development of major diseases. Drawing from real-world examples, historical context, and the latest scientific research, Dr. Reynolds walks through why glycation occurs, how modern diets have worsened its impact, and what strategies can help mitigate it. This video is designed to give viewers a practical, evidence-based understanding of how to protect their long-term metabolic health. Timestamps: 00:00 – Welcome to the College of Glycation 00:37 – What Is Glycation and Why It Matters 01:14 – How Glycation Happens: The Chemical Breakdown 03:11 – Blood Sugar and Glycation Acceleration 03:48 – History of Glycation and the Maillard Reaction 04:23 – Glycation and Disease: A1C, Aging, and More 05:48 – Eating AGEs: Processed Food and Diet Trends 06:33 – What the Science Says: Cell and Human Studies 08:32 – The Glycation-Sugar Connection 09:13 – Carbs, Fructose, and Modern Diets 10:32 – Ketosis: An Anti-Glycation Strategy 11:52 – Consequences of Glycation: Organs and Aging 13:09 – Oxidative Stress and the Glycation Feedback Loop 13:52 – What You Can Do: Diet and Lifestyle Solutions 14:31 – Final Thoughts and Next Steps Topics Covered -The chemical process of glycation and the formation of AGEs -The historical discovery of glycation and its relevance to human health -Research findings on glycation’s role in inflammation, diabetes, cardiovascular disease, and neurodegeneration -How modern diets increase glycation through carbohydrate and fructose intake -The benefits of ketosis and low-carbohydrate strategies for reducing glycation -Practical approaches to minimize glycation through diet and lifestyle About Dr. Paul Reynolds Dr. Paul Reynolds is a Professor of Cell Biology and Physiology at Brigham Young University. Known for his clarity in teaching complex biomedical concepts, Dr. Reynolds bridges cutting-edge research with practical health education. Through the College of Glycation series, he aims to make advanced metabolic science accessible and actionable for a broad audience. For more on glycation, metabolic health, and preventative strategies, subscribe to this channel and continue learning through the College of Glycation series. Questions or suggestions? Leave a comment below. #CollegeOfGlycation #DrPaulReynolds #Glycation #AGEs #MetabolicHealth #Healthspan #LowCarb #Ketosis #CellBiology #chronicdiseaseprevention Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)