The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this illuminating episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—delivers a deep exploration into the unsettling but increasingly clear connection between glycation and cancer. Building on earlier episodes about glycation’s role in aging, neurodegeneration, and cardiovascular disease, this lecture zeroes in on how sugar-derived molecular damage may be fueling cancer at nearly every stage—from DNA damage to tumor growth, invasion, and metastasis. Dr. Reynolds reveals how advanced glycation end products (AGEs) interact with key receptors like RAGE to create a pro-cancer environment marked by inflammation, oxidative stress, and matrix remodeling. He draws on cutting-edge peer-reviewed studies to examine how AGEs, insulin resistance, and hyperglycemia converge to promote tumor progression in cancers such as pancreatic, liver, colorectal, gastric, and breast. But it’s not all doom and gloom—this lecture is also packed with science-backed, actionable strategies to reduce AGE exposure, improve glycemic control, lower inflammation, and disarm one of cancer’s stealthiest metabolic weapons. Topics Covered: -Glycation basics: How AGEs are formed and why they matter -The Warburg effect and how cancer cells exploit glucose -AGE-RAGE signaling and its role in cancer progression and metastasis -Chronic inflammation as the silent enabler of malignancy -Insulin resistance as the molecular bridge between glycation and cancer -Dietary and lifestyle strategies to reduce glycation, improve metabolic resilience, and support cancer prevention Timestamps: 00:00 – Intro: Glycation & cancer overview 00:36 – How glycation may fuel tumor growth 01:14 – Glycation 101: AGEs and metabolism 01:57 – AGE–RAGE signaling & inflammation 02:38 – Glycation’s role in cancer biology 03:17 – Tumor metabolism: the Warburg effect 04:01 – Excess glucose, AGEs & cancer studies 04:46 – ECM remodeling & metastasis signals 05:28 – Oxidative stress & tumor environment 06:14 – Glycation and metastatic behavior 07:00 – Chronic inflammation & cancer risk 07:45 – NF-κB, cytokines, and immune evasion 08:32 – Inflammation-linked cancers: PDAC, liver, GI 09:15 – Pancreatic cancer & glucose metabolism 10:06 – Liver/colorectal/gastric cancers & glycation 10:52 – Insulin resistance: cancer’s hidden ally 11:34 – Hyperinsulinemia, PI3K/AKT & cell growth 12:21 – AGE–RAGE, inflammation & cancer cycle 13:03 – Breast cancer & glycemic control 13:47 – 6 strategies to reduce glycation risk 14:28 – 1: Control blood sugar (diet + exercise) 15:12 – 2: Antioxidants to fight oxidative stress 15:57 – 3: Anti-glycation compounds & supplements 16:34 – 4: Reduce dietary AGEs (cooking tips) 17:17 – 5: Anti-inflammatory lifestyle tips 17:58 – 6: Monitor glucose & cancer screenings 18:40 – Recap: break the glycation–cancer cycle 19:23 – Final thoughts: Stay informed, stay well Whether you’re managing chronic metabolic conditions or just want to reduce long-term cancer risk, this episode delivers powerful insights at the intersection of nutrition, metabolism, and oncology. About Dr. Paul Reynolds Dr. Reynolds is a passionate biomedical educator at Brigham Young University, known for his engaging, clear breakdowns of complex biochemical pathways. His College of Glycation series empowers viewers to take metabolic health into their own hands through a unique blend of science, storytelling, and practical application. #Cancer #CancerPrevention #Glycation #AGEs #Inflammation #OxidativeStress #Metabolism #InsulinResistance #CollegeOfGlycation #KetoDiet #LowCarb #HealthyAging #Wellness #AntiAging #NutritionScience #HealthEducation #SugarDamage #SciencePodcast #HealthyLiving #BiomedicalScience #BloodSugar #CellularHealth #ChronicDisease #ketocommunity Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)