The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (79 videos)
Topic Molecular damage that makes you older: which forms of aging damage can actually be reversed, which ones cannot, and why glycation cross-links on long-lived proteins sit firmly in the second category. Quick summary Not all aging damage is the same. Some of it can be cleared or rebuilt. Some of it cannot. Senescent cells can be removed. Mitochondria can be rebuilt with exercise. Autophagy can be stimulated. Most oxidized proteins get replaced. Cross-linking of long-lived proteins does not. Collagen in cartilage turns over on a timescale of more than a century. Nuclear pore proteins in brain cells can last a lifetime. Once glucosepane and other AGE cross-links form on those structures, current medicine has no way to remove them. The one serious cross-link breaker tested in humans failed. That leaves an asymmetry: reversible damage can be postponed. Permanent damage can only be prevented. For glycation, prevention means keeping post-meal glucose modest, limiting continuous high glycolytic flux (the source of methylglyoxal), supporting glutathione and glyoxalase, maintaining muscle, reducing dry-heat dietary AGEs, and not smoking. For complete show notes and references Become an Insider subscriber for the enhanced summary, timestamps, and links to every cited publication, plus the weekly newsletter, early episode access, the question portal, and Paul’s Weekly Research Review. Learn more: https://paulreynoldsphd.com Translation notes Click the gear icon at the bottom of this video to auto-translate captions. For French, for example: Subtitles → Auto-Translate → English first → Auto-Translate again → French. Note The information presented is for educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Paul Reynolds is a biomedical scientist and professor of cell biology, not a licensed clinician. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions. #HallmarksOfAging #Glucosepane #Methylglyoxal #CellularSenescence #Crosslinking #insulinresistance #Glycation #AGEs #inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #Ketodiet #LowCarb #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #KetoDiet #LowCarb #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth #Keto #KetoCommunity #HealthEducation Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerba mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)