The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (79 videos)
Topic Muscle loss, retention, and GLP-1s: why rapid weight loss can quietly reduce your body’s main glucose disposal tank, raise post-meal sugar exposure, accelerate glycation, and make the remaining muscle harder to rebuild. Summary Paul Reynolds, biomedical scientist and Professor of Cell Biology, addresses the most common question surrounding GLP-1 medications in this episode of the College of Glycation. Skeletal muscle disposes of roughly 80 % of insulin-stimulated glucose; losing a substantial share of lean tissue therefore reduces the body’s capacity to clear each meal, leaving glucose elevated longer and increasing glycation of circulating and structural proteins. Rapid weight loss on these drugs often includes 25–40 % lean mass, a proportion that is especially consequential for older adults and women with lower starting muscle. AGEs also accumulate on the long-lived collagen scaffold inside muscle, stiffening the extracellular matrix and impairing satellite-cell regeneration, creating a slow loop: less muscle → poorer glucose disposal → more AGEs → harder recovery of muscle. The science is nuanced—some lean-mass reduction is physiological and fat-free mass is not pure muscle—yet the risk is not uniform. Practical protection centers on high protein intake (1.2–1.6 g/kg), progressive resistance training, tracking body composition rather than scale weight alone, and titrating the dose so that protein intake and training remain feasible. Emerging agents such as bimagrumab show that muscle loss is solvable pharmacologically as well. These medications remain the most effective weight-loss tools available; the outcome depends on whether muscle is protected on the way down. References and more For complete show notes and references, we invite you to become an Insider subscriber. You'll enjoy a weekly newsletter, premier early access to College of Glycation episodes with full reprints of cited publications, a dedicated College of Glycation question portal with live recorded answers, Paul's Weekly Research Review Podcasts, and more. Learn more: paulreynoldsphd.com Translation Notes You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into French, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose French. NOTE The information presented is for educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Paul Reynolds is a biomedical scientist and professor of cell biology, not a licensed clinician. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions. #MuscleLoss #GLP1 #Sarcopenia #ResistanceTraining #BodyComposition #insulinresistance #Glycation #AGEs #inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #Ketodiet #LowCarb #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #KetoDiet #LowCarb #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth #Keto #KetoCommunity #HealthEducation Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds Full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)