The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this essential episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—unveils the overlooked connection between glycation and bone health. Building on previous explorations of glycation’s effects on the brain and heart, Dr. Reynolds now turns his attention to the skeletal system, revealing how sugar-related molecular damage silently erodes bone integrity, setting the stage for osteoporosis, osteoarthritis, and age-related bone fragility. At the heart of this episode is the collagen-rich matrix that gives bones their strength and flexibility—and how glycation compromises it by forming AGEs (advanced glycation end products). These crosslinking molecules stiffen collagen, impair remodeling, and trigger inflammation, accelerating matrix loss and weakening the skeleton. From postmenopausal osteoporosis to cartilage degradation in osteoarthritis, glycation emerges as a hidden saboteur of skeletal health. Dr. Reynolds also dives into insulin resistance, explaining how elevated blood sugar fuels AGE formation and worsens bone fragility, even in people whose bone density appears normal. Drawing on landmark studies and cutting-edge reviews, this lecture blends cellular biology, clinical insight, and practical wisdom. Most importantly, it equips viewers with strategies—dietary, lifestyle, and supplement-based—to slow bone loss and preserve structural resilience into old age. Topics Covered: -Glycation 101: What it is and why AGEs matter for bone tissue -How AGEs stiffen collagen and disrupt bone remodeling -The role of glycation in osteoporosis and osteoarthritis progression -Aging and bone fragility: glycation as a metabolic accelerator -Insulin resistance and its damaging impact on bone quality -Evidence-based strategies to reduce AGE burden and protect bones Timestamps: 00:00 - Intro to Glycation and Bone Health 01:17 - What Are AGEs and How They Form 02:44 - AGEs’ Effects on Bone Structure and Inflammation 04:07 - Bone Biology 101: Structure and Composition 06:18 - Ossification: How Bones Form 07:31 - Osteoblasts, Osteoclasts, and Osteocytes 08:22 - Glycation Targets Bone Matrix 09:06 - Progressive Matrix Loss Explained 10:41 - Glycation’s Role in Osteoporosis 11:21 - Osteoarthritis and AGE Accumulation 12:51 - Aging, Glycation, and Bone Fragility 13:35 - IGF-1, Glycation, and Aging Bones 15:10 - Insulin Resistance Fuels Glycation 16:50 - Diabetes and Skeletal Fragility 17:32 - Strategies to Prevent Glycation-Induced Bone Loss 18:49 - Diet, Exercise, and Supplement Approaches 20:10 - Avoiding Dietary AGEs and Optimizing Bone Health 20:59 - Final Thoughts and Takeaways 21:17 - Stay Sharp, Stay Healthy Whether you’re managing diabetes, navigating menopause, or simply aiming to maintain skeletal strength as you age, this episode offers the insights—and the tools—you need to safeguard your bones from the inside out. About Dr. Paul Reynolds: Dr. Reynolds is a biomedical scientist and beloved professor at Brigham Young University. Through the College of Glycation series, he demystifies complex metabolic processes and empowers individuals to take charge of their health through cutting-edge science and actionable advice. #Bone #BoneHealth #Arthritis #Osteoarthritis #Glycation #AGEs #Inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #KetoDiet #LowCarb #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth #Keto #KetoCommunity #healtheducation Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)