The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this essential episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—dives deep into the devastating impact of glycation on cardiovascular health. Building on his prior exploration of glycation’s role in neurodegeneration, Dr. Reynolds now reveals how sugar-related molecular damage sets the stage for heart disease, stroke, hypertension, and vascular dysfunction. Glycation, through its toxic byproducts known as AGEs (advanced glycation end products), acts like a molecular saboteur—stiffening arteries, inflaming tissues, and accelerating atherosclerosis. Paired with insulin resistance, this biochemical duo becomes a major driver of heart attacks and cardiovascular mortality. Dr. Reynolds unpacks the science with clarity, drawing on peer-reviewed studies and clinical insights to illuminate why glycation isn't just a diabetic concern—it's a universal cardiovascular threat. This lecture explores the historical arc of glycation research, from foundational discoveries in the 1980s to cutting-edge biomarker trends today. Most importantly, it empowers viewers with knowledge and actionable steps to protect heart health by reducing AGE exposure and tackling insulin resistance through diet and lifestyle. Topics Covered: -What glycation is and how AGEs form -How AGEs damage arteries and promote hypertension -The link between glycation, inflammation, and atherosclerosis -Insulin resistance as a metabolic amplifier of cardiovascular disease -Evidence-based strategies to lower AGE burden and improve heart function Timestamps: 00:00 - Introduction to Glycation and Cardiovascular Disease 00:36 - What Are AGEs (Advanced Glycation End Products)? 01:15 - How AGEs Trigger Cardiovascular Disease 02:36 - Hypertension and AGEs 03:53 - AGEs and Atherosclerosis 04:36 - Vessel Stiffening and Endothelial Dysfunction 05:16 - Heart Health and Diabetic Cardiomyopathy 05:57 - Stroke and Heart Attacks 07:19 - Insulin Resistance: The Engine Behind Glycation 08:39 - The Vicious Cycle: AGEs Worsen Insulin Resistance 09:20 - AGEs and Endothelial Dysfunction 09:57 - AGEs and Heart Failure Risk 10:37 - Historical Background: From Brownlee to Modern Research 11:15 - The AGE-RAGE Axis in Atherosclerosis 11:57 - Solutions: AGE Inhibitors and Lifestyle 12:37 - Dietary AGEs and Heart Health 13:15 - Biomarkers and Skin Autofluorescence 13:58 - Metabolic Memory and Long-Term Damage 14:40 - Summary and Final Thoughts 15:19 - Practical Advice and What’s Next Whether you're navigating diabetes, heart disease, or simply seeking to future-proof your vascular health, this episode offers the tools and science to take action. About Dr. Paul Reynolds Dr. Reynolds is a dynamic educator and biomedical scientist at Brigham Young University, known for making complex metabolic pathways both understandable and engaging. His College of Glycation series empowers individuals to confront the silent molecular processes that drive aging and chronic disease. #Glycation #AGEs #inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #HeartHealth #Hypertension #CardiovascularDisease #Atherosclerosis #stroke #HeartAttack #HealthyHeartDiet #Ketodiet #LowCarb #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #KetoDiet #LowCarb #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth #PodcastEpisode #Keto #KetoCommunity #healtheducation Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)