The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this must-watch episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—uncovers the powerful connection between glycation and visible aging, especially its destructive effects on skin and connective tissue. Building on previous episodes, Dr. Reynolds now explores how advanced glycation end products (AGEs) sabotage collagen, elastin, and cellular repair, accelerating skin wrinkling, tissue stiffness, and systemic degeneration. AGEs are more than just cosmetic enemies—they are metabolic wrecking balls. Dr. Reynolds delves into how these molecules damage long-lived structural proteins, promote oxidative stress, activate harmful inflammation via the RAGE receptor, and worsen insulin resistance. Drawing on cutting-edge dermatological and metabolic research, he explains how what shows up on the skin often mirrors what's happening inside your blood vessels, nerves, and organs. This lecture charts the historical journey of glycation science, from its Maillard reaction roots to today’s non-invasive diagnostic tools like skin autofluorescence. It also offers clear strategies to fight back—through diet, lifestyle, and targeted compounds that reduce AGE formation and insulin resistance. Topics Covered: -How AGEs form and damage skin structure -The role of collagen and elastin cross-linking in skin aging -UV exposure and oxidative stress as AGE accelerants -RAGE activation and its link to inflammation and pigmentation -Insulin resistance as a fuel for glycation -Systemic tissue damage beyond the skin -Evidence-based ways to lower AGEs and improve skin and metabolic health Timestamps: 00:00 – Introduction to Glycation and Aging 00:40 – How AGEs Damage Skin, Collagen, and Deeper Tissues 01:20 – What Is Glycation? The Non-Enzymatic Sugar Reaction 02:01 – AGE Formation and Early Discoveries 02:40 – Glycation’s Role in Skin Aging and Collagen Damage 03:21 – AGEs: The Molecular Rust Behind Wrinkles and Sagging 03:59 – Inflammation and Systemic Disruption Caused by AGEs 04:40 – Why Collagen Turnover Is So Slow and Vulnerable 05:22 – AGE Cross-Linking and Visible Signs of Skin Aging 06:05 – UV Radiation and Oxidative Stress Accelerate AGE Formation 06:50 – CML, Elastin Clumping, and the Leathery Skin Effect 07:31 – RAGE Activation, Inflammation, and Hyperpigmentation 08:14 – How Glycation Blocks Skin Repair and Regeneration 08:56 – Collagen and Elastin Breakdown Under Glycation Stress 09:37 – Why Glycated Collagen Can't Be Recycled 10:19 – Photoaging, Solar Elastosis, and Elastin Clumps 11:04 – Wound Healing, Diabetes, and Glycated Skin Markers 11:41 – Glycation’s Systemic Impact Beyond the Skin 12:22 – AGEs and Cardiovascular Stiffness in Diabetics 13:04 – Glycation’s Role in Kidney and Nerve Damage 13:46 – Skin as a Reflection of Internal Health 14:25 – Insulin Resistance: A Metabolic Driver of Glycation 15:05 – The Vicious Cycle: AGEs Worsen Insulin Resistance 15:48 – Skin Autofluorescence and AGE Biomarkers 16:28 – Oxidative Stress, Free Radicals, and Cellular Damage Whether you're concerned with skin appearance, aging, or deeper metabolic dysfunction, this episode provides essential tools to protect your cells—and your reflection. About Dr. Paul Reynolds Dr. Reynolds is a compelling educator and biomedical researcher at Brigham Young University, known for making complex biochemical processes approachable and empowering. Through the College of Glycation series, he helps audiences understand the silent mechanisms driving aging and chronic disease—so they can take science-backed action. #Glycation #AGEs #inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #SkinHealth #Skin #Aging #Collagen #Sunspots #HealthySkinDiet #Ketodiet #LowCarb #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #KetoDiet #LowCarb #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth #PodcastEpisode #Keto #KetoCommunity #healtheducation Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)