The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this essential episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—uncovers how glycation wreaks havoc on your gut, revealing its surprising role in leaky gut, microbiome imbalance, inflammatory bowel disease (IBD), and insulin resistance. Glycation, driven by sugar-induced molecules called AGEs (advanced glycation end products), doesn’t just affect your heart or brain—it targets your digestive system at its core. Through inflammatory signaling and gut barrier breakdown, AGEs compromise gut health, fostering conditions like Crohn’s disease, ulcerative colitis, and systemic inflammation. Dr. Reynolds expertly explains the science behind these molecular assaults, weaving in groundbreaking research and practical advice to help viewers reclaim their gut health. This lecture journeys from the biochemical chaos AGEs unleash in the gut lining and microbiome, to the emerging understanding of their role in metabolic disease. But it’s not all doom and gloom—Dr. Reynolds also delivers actionable strategies to fight back using diet, microbiome support, anti-inflammatory tools, and blood sugar control. Topics Covered: -How glycation disrupts your gut lining and microbiome -The connection between AGEs and leaky gut -The role of AGEs in IBD, IBS, and colorectal cancer -How insulin resistance worsens gut damage -Strategies to reduce dietary AGEs and protect gut health Timestamps: 00:00 – Intro & why gut health matters 00:38 – Leaky gut, glycation refresher 01:16 – How AGEs form & cause damage 01:58 – AGEs in food & inflammation 02:37 – RAGE receptors & tissue damage 03:17 – Gut: frontline for AGE impact 03:59 – Leaky gut & tight junctions 04:42 – Microbiome disruption 05:22 – Loss of good bacteria 06:07 – AGEs & gut diseases (IBD) 06:52 – Oxidative stress in IBD 07:33 – Vicious cycle of inflammation 08:19 – IBS, colorectal cancer links 09:03 – Insulin resistance & gut damage 09:43 – AGE-insulin feedback loop 10:24 – Microbiome reshaping 11:07 – Broader disease connections 11:52 – Cut dietary AGEs (cooking tips) 12:36 – Feed your microbiome (fiber, ferments) 13:58 – Control blood sugar 14:42 – Antioxidants & anti-glycation 15:23 – Reduce inflammation naturally 16:06 – Gut health = whole-body health 16:46 – Recap & key takeaways 17:26 – Final advice & closing Whether you're battling gut issues, prediabetes, or simply aiming to optimize digestion, this episode delivers the science and solutions you need to take control of your health from the inside out. About Dr. Paul Reynolds Dr. Reynolds is a dynamic educator and biomedical scientist at Brigham Young University, known for making complex metabolic pathways both understandable and engaging. His College of Glycation series empowers individuals to confront the silent molecular processes that drive aging and chronic disease. #GutHealth #Microbiome #GutMicrobiome #HealthyGut #GutHealing #DigestiveHealth #InflammatoryBowelDisease #IBD #CrohnsDisease #LeakyGut #Glycation #AGEs #inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #Ketodiet #LowCarb #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #KetoDiet #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth #Keto #KetoCommunity #healtheducation Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)