The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this essential episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—unpacks the hidden link between glycation and allergies. Building on previous episodes about sugar's impact on neurodegeneration and cardiovascular disease, Dr. Reynolds now explores how advanced glycation end products (AGEs) may be fueling seasonal sniffles, sinus issues, and even asthma. With striking clarity and insight, he explains how glycation weakens epithelial barriers, amplifies Th2 immune responses, and makes your body more reactive to everyday allergens like pollen and food proteins. It’s not just about sugar and inflammation—it’s about how metabolic dysfunction, driven by insulin resistance and poor diet, creates the perfect storm for allergic overdrive. Drawing on peer-reviewed studies, Dr. Reynolds exposes the pathways that turn glycation into a chronic allergic amplifier—and offers science-backed ways to fight back. Topics Covered: -How glycation weakens your immune barriers and worsens allergies -The role of AGEs in asthma, sinusitis, and food sensitivities -How insulin resistance drives immune overactivation and oxidative stress -The dangerous cycle of hyperglycemia, AGEs, and chronic inflammation -Dietary and lifestyle strategies to lower AGEs and strengthen immune resilience Timestamps: 00:00 – Introduction to Glycation and Allergies 00:38 – Glycation’s Role in Immune Dysfunction 01:17 – What Are AGEs and How Do They Form? 02:00 – Dietary AGEs and the Maillard Reaction 02:37 – How Glycation Impacts Allergies 03:19 – Epithelial Damage and RAGE Activation 04:04 – TH2 Immunity and Allergy Amplification 04:48 – Allergy Symptoms and the Glycation Cascade 05:32 – Chronic Inflammation and Asthma Risk 06:13 – Cytokines, Fatigue, and Reduced Focus 06:53 – Processed Foods as AGE Bombs 07:33 – Insulin Resistance Fuels Glycation 08:15 – Metabolic Dysfunction and Immune Overactivation 08:58 – ER Stress, Mitochondrial Dysfunction, and IR 09:39 – Junk Food, Stress, and Allergy Flare-Ups 10:19 – Food Allergies and Epithelial Disruption 11:01 – Inflammatory Cytokines and Asthma Pathways 11:39 – Strategies to Reduce Glycation 12:18 – Antioxidants and AGE Blockers 12:57 – Dietary Tips to Lower AGE Burden 13:43 – Summary: Control Glycation, Control Allergies Whether you struggle with springtime sneezing or year-round asthma, this episode sheds new light on the metabolic roots of immune dysfunction—and how to regain control. About Dr. Paul Reynolds Dr. Reynolds is a dynamic educator and biomedical scientist at Brigham Young University, known for making complex metabolic pathways understandable and actionable. His College of Glycation series equips viewers with tools to fight the hidden molecular drivers of chronic disease and aging. #Allergies #ImmuneHealth #SeasonalAllergies #Rhinitis #Sneezing #Glycation #AGEs #Inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #KetoDiet #LowCarb #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth #KetoCommunity #healtheducation Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)