The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this foundational lecture for the College of Glycation, Dr. Paul Reynolds explores how glycation disrupts the immune system, accelerating aging, inflammation, and chronic disease vulnerability. He explains how sugar-induced damage—through advanced glycation end products (AGEs)—interferes with key immune cells, weakens antibodies, and fuels conditions like diabetes, rheumatoid arthritis, and even cancer susceptibility. By weaving together compelling peer-reviewed research, clinical insight, and actionable solutions, Dr. Reynolds highlights the link between glycation, immune dysfunction, and insulin resistance. This episode empowers viewers with practical steps to defend their immune system—through blood sugar control, low-AGE diets, and smart lifestyle choices. Topics Covered -What glycation is and how AGEs form in the body -How AGEs impair immune cells like macrophages, T-cells, and B-cells -The AGE-RAGE axis and how it fuels chronic inflammation -Why insulin resistance worsens glycation and weakens immunity -The role of glycation in diabetes, rheumatoid arthritis, and infections -How to protect your immune system with diet, exercise, and antioxidants Timestamps: 00:01 – Welcome to the College of Glycation 00:38 – Glycation and the Immune System 01:16 – How AGEs Form and Why They Matter 02:00 – AGEs, Inflammation, and Immune Cell Damage 02:39 – Glycation and Immune Dysfunction Overview 03:17 – The Two Branches of the Immune System 04:03 – B-Cells, T-Cells, and Antibody Basics 04:44 – The AGE-RAGE Inflammatory Pathway 05:29 – Macrophages and Immune Cell Impairment 06:13 – Antibodies as Glycation Targets 06:56 – IgG Dysfunction from Glycation 07:38 – Weaker Immunity and Infection Risk 08:22 – Glycation’s Role in Aging the Immune System 09:11 – Immunosenescence and Insulin Resistance 09:53 – Insulin Resistance Fuels More Glycation 10:31 – Glycation, Inflammation, and Immune Signaling 11:15 – Diabetes, Immune Dysfunction, and Wound Healing 12:00 – Autoimmunity and Glycation: RA and IgG4 Disease 12:41 – Infections and Diabetic Immune Vulnerability 13:28 – Solutions: Diet, Movement, Antioxidants 14:06 – Exercise and Insulin Sensitivity 14:46 – Antioxidants and Cooking Methods 15:29 – Avoiding Dietary AGEs 16:08 – Final Thoughts: Stay Curious, Stay Healthy 16:50 – Outro: Glycation, Immunity & Lifelong Health About Dr. Paul Reynolds Dr. Paul Reynolds is a Professor of Cell Biology and Physiology at Brigham Young University. Known for his engaging, research-informed teaching style, Dr. Reynolds makes complex biomedical topics approachable and relevant. Through the College of Glycation series, he empowers viewers to understand and prevent the silent processes that drive chronic disease and accelerated aging. For more science-backed insights on glycation, oxidative stress, and metabolic health, subscribe and continue learning with the College of Glycation series. Questions? Leave a comment below. #CollegeOfGlycation #DrPaulReynolds #ImmuneSystem #ImmuneHealth #Glycation #AGEs #InsulinResistance #ChronicInflammation #Diabetes #Antibodies #HealthyAging #KetoDiet #LowCarb #NutritionScience #HealthPodcast #CellularHealth #BloodSugar #MetabolicHealth #AntiAging #HealthyLiving #SciencePodcast #Wellness #HealthEducation #BiomedicalScience #KetogenicDiet #Healthspan #Inflammation Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)