The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this foundational lecture for the College of Glycation, Dr. Paul Reynolds unpacks the role of glycation in driving cognitive decline, mental health disorders, and neurodegenerative diseases like Alzheimer’s and Parkinson’s. He explains how sugar-related damage—via advanced glycation end products (AGEs)—disrupts brain function, fuels inflammation, and accelerates aging. By weaving together compelling scientific evidence, clinical insights, and practical strategies, Dr. Reynolds highlights how glycation—and its close partner, insulin resistance—create a metabolic storm that harms memory, mood, and long-term brain health. This episode equips viewers with knowledge and tools to combat glycation through diet and lifestyle, with a special focus on the promise of ketogenic therapies. Topics Covered -What glycation is and how AGEs form in the body -How glycation affects the brain and contributes to Alzheimer’s, Parkinson’s, and dementia -The link between insulin resistance, blood sugar, and cognitive dysfunction -Why conventional diabetes medications fall short in protecting brain health -The neuroprotective potential of ketosis and low-AGE diets -Actionable steps to reduce glycation and support long-term cognitive function Timestamps: 00:00 – Introduction: Welcome to the College of Glycation 00:39 – What is glycation? (Basics & AGE formation) 01:21 – Glycation explained: From browning to tissue damage 02:01 – Health impact: Arteries, skin, and chronic disease links 02:44 – Dual pathways: Endogenous vs. exogenous glycation 03:29 – Endogenous glycation: Produced inside the body 04:18 – Aging, oxidative stress, and organ clearance 05:00 – Exogenous glycation: Dietary sources (cooking & food) 05:41 – How much is absorbed? The 10% dietary retention 06:27 – Comparing endogenous vs. exogenous burden 07:07 – Genetics, lifestyle, and diet influence 07:54 – Long-lived proteins, collagen, and chronic disease 08:40 – Shared damage: Skin, arteries, joints, kidneys, eyes 09:23 – Recent studies on glycation and health risks 10:07 – Dual threat: Managing internal vs. external AGEs 10:54 – Dietary strategies & reducing processed foods 11:34 – Ketosis, diet shifts, and prevention 12:16 – Conclusion & closing remarks About Dr. Paul Reynolds: Dr. Paul Reynolds is a Professor of Cell Biology and Physiology at Brigham Young University. Known for his engaging, research-informed teaching style, Dr. Reynolds makes complex biomedical topics approachable and relevant. Through the College of Glycation series, he empowers viewers to understand and prevent the silent processes that drive chronic disease and accelerated aging. For more science-backed insights on glycation, oxidative stress, and metabolic health, subscribe and continue learning with the College of Glycation series. #CollegeOfGlycation #DrPaulReynolds #CognitiveDecline #Glycation #AGEs #AlzheimersDisease #Parkinsons #BrainHealth #InsulinResistance #MentalHealth #KetogenicDiet #HealthyBrainAging #MetabolicHealth #Neurodegeneration #NutritionScience #LowCarb #KetoDiet #Healthspan #SciencePodcast #CellBiology #HealthyLiving #BloodSugar #AntiAging Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)