The College of Glycation is an educational video series dedicated to helping viewers understand one of the most critical and often overlooked processes in human biology: glycation. Led by Dr. Paul Reynolds, Professor of Cell Biology and Physiology at Brigham Young University, this series explores how sugar interacts with proteins and fats in the body, forming harmful compounds called Advanced Glycation End-products (AGEs). These compounds accelerate aging, contribute to chronic diseases, and play a key role in metabolic dysfunction. Each video is designed to break down complex topics into clear, practical insights. Whether you’re a healthcare professional, student, or simply someone seeking to improve your health, this series will give you a deeper understanding of the biological roots of inflammation, insulin resistance, and cellular damage—and what you can do to address them.
Curated by: PaulReynoldsPhD (74 videos)
In this powerful episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores the remarkable intersection between ketones and glycation, revealing how ketone metabolism can counteract one of the most destructive biochemical processes driving aging and chronic disease. Building on earlier discussions about AGEs, he explains how elevated glucose fuels inflammation, oxidative stress, tissue damage, and metabolic dysfunction—and how ketones, especially BHB, can break that cycle. Drawing on cutting-edge research and his own laboratory findings, Dr. Reynolds details how ketones serve as both clean-burning fuel and potent signaling molecules that reduce glycation pressure, stabilize blood sugar, suppress inflammatory pathways like NLRP3, and improve mitochondrial efficiency. He also highlights compelling evidence showing how ketogenic diets lower HbA1c, reduce oxidative stress, protect cells from glycation, and enhance metabolic resilience—while his lab’s work demonstrates the protective effects of BHB in obesity, hyperuricemia, and RAGE-driven metabolic disruption. This episode also equips viewers with practical strategies for lowering AGEs and improving metabolic health, including low-glycemic eating, low-AGE cooking methods, exercise, fasting, and targeted supplementation with exogenous ketones. Topics Covered -What glycation is and how AGEs form -Insulin resistance, hyperinsulinemia & chronic sugar exposure -How glycation triggers inflammation & oxidative stress -How ketones lower glycation and stabilize metabolic health -BHB as a signaling molecule that reduces inflammation -Ketosis and mitochondrial efficiency -Dietary & lifestyle strategies to reduce AGE accumulation -Low-AGE cooking, antioxidants & metabolic flexibility -Exogenous ketones as tools for glycation reduction -Research insights from Dr. Reynolds’ laboratory Timestamps 00:00:01 – Introduction: Ketones & Glycation 00:00:42 – Why Ketones Matter Beyond Weight Loss 00:01:24 – Welcome to the College of Glycation 00:02:01 – How Ketones Fit Into Metabolic Health 00:02:37 – What Glycation Is (Refresher) 00:03:18 – Advanced Glycation End Products (AGEs) Explained 00:03:57 – Why Excess Glycation Damages the Body 00:04:36 – Insulin Resistance: A Key Player 00:05:16 – How Insulin Resistance Develops 00:05:59 – Glycation & Insulin Resistance Feedback Loop 00:06:40 – Ketones Suppressed by High Insulin 00:07:22 – Introducing Ketones: What They Are 00:08:07 – Nutritional Ketosis vs. Ketoacidosis 00:08:52 – Ketones Improve Mitochondrial Efficiency 00:09:36 – BHB as a Signaling Molecule 00:10:23 – Ketones as Anti-Glycation Agents 00:11:10 – How Ketosis Reduces Glycation Pressure 00:11:53 – BHB & Inflammation (NLRP3 Inflammasome) 00:12:40 – Ketosis & Metabolic Flexibility 00:13:25 – Research on Ketosis Reducing AGE Accumulation 00:14:07 – Dr. Reynolds’ Lab: BHB & Fat Loss 00:14:55 – BHB Protects Against Uric Acid Damage 00:15:40 – RAGE Knockout & Resistance to Obesity 00:16:23 – Human & Animal Research on Ketones & AGEs 00:17:07 – Unanswered Questions About Ketosis & Aging 00:17:49 – Practical Strategies: Diet & Low-AGE Cooking 00:18:34 – Intermittent Fasting & Glycation Reduction 00:19:18 – Exogenous Ketones: Benefits & Limitations 00:19:59 – Closing Thoughts & Takeaways Whether you're looking to reverse insulin resistance, reduce glycation-driven aging, or optimize metabolic flexibility, this episode offers science-backed strategies to help you protect cellular health, sharpen metabolism, and improve long-term vitality. About Dr. Paul Reynolds Dr. Reynolds is a biomedical scientist and educator at Brigham Young University, known for translating complex metabolic biology into clear, actionable guidance. Through the College of Glycation, he unpacks the hidden biochemical forces shaping health, aging, and resilience. #ketones #exogenousketones #insulinresistance #diabetes #obesity #Glycation #AGEs #Inflammation #OxidativeStress #Redox #CollegeOfGlycation #KetoDiet #HealthyAging #SugarDamage #HealthPodcast #AntiAging #Nutrition #Wellness #SciencePodcast #HealthyLiving #CellularHealth #KetoCommunity #healtheducation Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)