The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works. Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets. In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.
Curated by: Andrew Huberman (417 videos)
My guest is Dr. David Fajgenbaum, MD, professor of translational medicine and human genetics at the University of Pennsylvania. He explains how, unbeknownst to most doctors, many approved medications can successfully treat or even cure diseases other than the ones they are typically used to treat. He shares his story of escaping death from Castleman's disease by discovering a life-saving treatment using repurposed drugs that were approved for other purposes. Our conversation explores how researchers, physicians, and you—the general public—can explore novel treatments and cures to conditions the medical profession has deemed untreatable, including cancers. We also discuss the crucial role of mindset in battling diseases and the lesser-known use of compounds to promote health and longevity. Episode show notes: https://go.hubermanlab.com/4ER98fx *Thank you to our sponsors* AGZ by AG1: https://drinkagz.com/huberman Eight Sleep: https://eightsleep.com/huberman Rorra: https://rorra.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *Dr. David Fajgenbaum* Website: https://davidfajgenbaum.com Academic profile: https://www.med.upenn.edu/apps/faculty/index.php/g275/p8205911 TED talk: https://davidfajgenbaum.com/#ted Support Every Cure’s mission: https://everycure.org/ted Cytokine Storm Treatment & Laboratory: https://www.med.upenn.edu/CSTL Chasing My Cure (book): https://amzn.to/49Ea3Fg Time100 Health 2025: https://time.com/collections/time100-health-2025/7279645/david-fajgenbaum Instagram: https://www.instagram.com/dfajgenbaum X: https://x.com/DavidFajgenbaum Facebook: https://www.facebook.com/davidfajgenbaum LinkedIn: https://www.linkedin.com/in/davidfajgenbaum *Timestamps* 00:00:00 David Fajgenbaum 00:04:06 Self-Agency in Healthcare; New Uses for Old Medicines 00:06:44 Other Uses of Aspirin & Viagra; Drug Development & Approved Use 00:08:53 Lidocaine & Breast Cancer; Pharmaceutical Companies & Incentives 00:11:36 Sponsors: Eight Sleep & Rorra 00:14:16 Pharmaceutical Companies, Patents & New Uses; Lithium 00:18:40 Tools: Finding Reliable Health Sources, Asking Questions & Disease Organizations; DADA2 Treatment 00:21:53 Medical Community & Connections; Integrated Medical Databases 00:24:36 Drug Repurposing, Thalidomide, Pembrolizumab 00:28:45 Medical Research Databases, Mapping Disease Connections 00:33:51 Every Cure Database & Programs, Bachmann-Bupp Syndrome; Colchicine & Heart Disease 00:37:57 Sponsors: AGZ by AG1 & David 00:40:41 David’s Medical & Career Journey, Glioblastoma, Castleman Disease 00:49:10 Autoimmune Disease, Driven Personality, Stress & Immune System 00:52:52 Castleman Disease, Treatment, Chemotherapy 00:55:54 Physician Continuing Education, Santa Claus Theory of Civilization; Science Collaboration 01:03:32 Medical School, Relapse & “Overtime”, Finding a New Treatment, Rapamycin 01:12:46 Sport, Football & Resilience; Challenge & Personal Growth, Family 01:18:41 Sponsor: Function 01:20:29 Social Support; “Overtime”, Gratitude 01:23:19 Business School, Castleman Disease Treatment; Repurposing Drugs & AI 01:28:29 Drug Repurposing, POEMS Syndrome; Mitigating Risk 01:35:32 Nicotine, Compounds for Preventive Health; GLP-1 Agonists 01:40:51 Bioprospecting, Drug Development; AI, Prioritization & Novel Connections 01:46:18 Healthcare & Children; Hope, Action & Impact Circuit; Challenge & Super-Agers 01:52:50 Get Involved with Every Cure 01:56:20 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter #HubermanLab #Science #Health Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer