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Currently Playing: Claude Mythos 5.2 predicts the structure of a therapy capsid

Claude Mythos 5.2 predicted the structure of a whole AAV capsid, the protein shell used to deliver gene therapies. The capsid is 60 copies of one protein chain. Claude wrote code that runs open-source folding models on overlapping groups of five neighboring chains, then uses the capsid’s symmetry to stitch all 60 together. On AAV2, its prediction landed within about the width of an atom of the experimental structure. Learn more: https://www.anthropic.com/claude-fable-and-mythos-5-2