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Currently Playing: Why Alcoholism is a Disease

We could all use more empathy in our world. Glossary Neuropeptide Y (NPY): This is a neurotransmitter. In the amygdala, it's presence is experimentally shown to reduce stress and anxiety Histone Acetyltransferase (HAT): These proteins add acetyl groups to histones which causes the surrounding DNA to loosen up and be available for transcription. Histone Deacetylase (HDAC): These proteins remove acetyl groups from histones which causes the surrounding DNA to tighten up around the histone. DNA Methyltransferase (DNMT): This protein can add methyl groups to CpG islands in the DNA. This can block transcription factors from binding to a gene promoter region preventing its transcription CpG Island: A cytosine-phosphate-guanine island is a section of DNA with a large numb of Cytosine followed by guanine pairs. These are usually found at gene promoter regions. CBP: CREB-Binding protein is a transcription factor with intrinsic HAT activity. It is shown to promote the transcription of NPY in the amygdala Sources: EPIGENETIC MECHANISMS OF ALCOHOLISM AND STRESS-RELATED DISORDERS (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464725/) Epigenetic Control of Gene Expression in the Alcoholic Brain(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860426/) Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene (https://doi.org/10.1016/S0165-6147(03)00226-8) Epigenetics—Beyond the Genome in Alcoholism (https://pubs.niaaa.nih.gov/publications/arcr343/293-305.htm) Kinda like the music? Checkout more at: https://dopeminemusic.bandcamp.com/