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Currently Playing: My friend got prion disease. We watched her forget who we are.

Review: Dr Katherine Johns In-depth channel: @HemeReview Secret channel: @BigEmus Music inspired by R Prince (RIP) performed by Chubbyemu More music by @Lifeformed Medicine ► https://www.youtube.com/playlist?list=PL26HeTCO57qcMQB6CrU6QRzEi9tt9l1FI These cases are patients who I, or my colleagues have seen. In this particular video, it's an actual colleague of mine who got prion disease. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet. Selected References: [In German] Cohn F. Untersuchungen über Bacterien. II. Beiträge zur Biologie der Pflanzen. (Investigations into Bacteria. II. Contributions to the Biology of Plants.) 1875;1(3):141–208. [In German] Beijerinck, M. W. (1898). “Ueber ein Contagium vivum fluidum als Ursache der Fleckenkrankheit der Tabaksblätter.” https://books.google.com/books?id=29UjMyncrkcC [In German] Creutzfeldt HG. Über eine eigenartige herdförmige Erkrankung des Zentralnervensystems (vorläufige Mitteilung) Z Gesamte Neurol Psy. (About a peculiar focal disease of the central nervous system (preliminary communication)) 1920;57:1–18. https://books.google.com/books?hl=en&lr=&id=sfwSAQAAMAAJ&oi=fnd&pg=PA1&ots=7dVQ9VzTYz&sig=bp1Dy9UZitqFZ0CIig6AAeNlMsM [In German] Jakob AM. Über eigenartige erkrankungen des zentralnervensystems mit bemerkenswertem anatomischen befunde. (On peculiar diseases of the central nervous system with remarkable anatomical findings.) 1920. https://link.springer.com/article/10.1007/BF02870932 Studies on the heat stability and chromatographic behaviour of the scrapie agent. https://pubmed.ncbi.nlm.nih.gov/14247749/ Degenerative Disease of the Central Nervous System in New Guinea — The Endemic Occurrence of Kuru in the Native Population. https://www.nejm.org/doi/10.1056/NEJM195711142572005 Observations on kuru. III. Pathological features in five cases. https://pubmed.ncbi.nlm.nih.gov/13638205/ Kuru. Clinical, pathological and epidemiological study of an acute progressive degenerative disease of the central nervous system among natives of the Eastern Highlands of New Guinea. https://www.amjmed.com/article/0002-9343(59)90251-7/abstract Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction. https://pmc.ncbi.nlm.nih.gov/articles/PMC4235695/ Hadlow WJ. Scrapie and kuru. https://www.cabidigitallibrary.org/doi/full/10.5555/19602200703 A brief history of prions. https://pmc.ncbi.nlm.nih.gov/articles/PMC4626585/ Novel proteinaceous infectious particles cause scrapie. https://pubmed.ncbi.nlm.nih.gov/6801762/ [URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae. https://pubmed.ncbi.nlm.nih.gov/7909170/ A novel progressive spongiform encephalopathy in cattle. (First Mad Cow Disease, Bovine Spongiform Encephalopathy BSE Description) https://pubmed.ncbi.nlm.nih.gov/3424605/ Sporadic Creutzfeldt-Jakob Disease Brain MRI courtesy of Lourdes Simbrón Ribbeck, Radiopaedia.org, rID: 66154